.NET 4.6.1, .NET 4.5.2 AND CRM 2016

I have Net 4.5.2, in Windows 2012 R2, and CRM 2016 installed.

I use VS 2013.

I want créate WCF Services .NET 4.6.1, and hosting in IIS 8.5 in the  Windows 2012 R2 + CRM 2016 server.

CRM 2016 manages Net 4.5.2.

Any problems if I install  Targeting Pack .NET Framework 4.6.1 ?